Research Interests

Harnessing advanced microscopy and computational analyses to extract information on the relationships and dynamics of molecules in their native cellular contexts.

Improving the quality and usability of scientific software.

More open, collaborative science.

Education

PhD, Biological and Biomedical Sciences, Emory University

BS, Program in Biological Chemistry, Bates College

Certificate, Software Engineering, Harvard University

Software Highlights

Hemocytometer Sidekick - Easier cell counting with a hemocytometer. Available in iOS/Android/Windows app stores. Source not yet public.

SimpleANOVA.jl - Analysis of Variance package for the Julia language, for those who prefer to stay away from linear models.

Q-SCAn - Package implementing Quantitative Subcellular Compartmentalization Analysis developed for use with Cell Profiler and ImageJ to quantify the distribution of a protein among cellular compartments.

Scryptonite - Built the scrypt cryptographic algorithm from the source paper and released it as a component for Universal Windows Platform apps. Available on Nuget.

View on Github

Paper Highlights

Bauer NC, Yang A, Wang X, Zhou Y, Klibanski A, Soberman RJ. A cross–nearest neighbor/Monte Carlo algorithm for single molecule localization microscopy defines interactions between p53, Mdm2, and MEG3. bioRxiv. [Preprint]. doi:10.1101/857912

Schmider AB, Bauer NC (co-first), Sunwoo H, Godin MD, Ellis GE, Lee JT, Nigrovic PA, Soberman RJ. The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses. J Biol Chem. 295(17):5761-5770. doi:10.1074/jbc.RA119.012069

Schmider AB, Vaught M, Bauer NC, Elliott HL, Godin MD, Ellis GE, Nigrovic PA, Soberman RJ. The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses. PLoS One. 2019;14(2):e0211943. Published 2019 Feb 8. doi:10.1371/journal.pone.0211943

Bauer NC, Corbett AH, Doetsch PW. The current state of eukaryotic DNA base damage and repair. Nucleic Acids Res. 2015;43(21):10083–10101. doi:10.1093/nar/gkv1136

Bauer NC, Doetsch PW, Corbett AH. Mechanisms regulating protein localization. Traffic. 2015;16(10):1039–1061. doi:10.1111/tra.12310

Bauer NC, Corbett AH, Doetsch PW. Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn. Traffic. 2013;14(12):1200–1208. doi:10.1111/tra.12118